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leukeran 2mg In approaching this central problem, Neuberger knew that a process distinct from that of cutting and pasting of the antibody genes came into play when an antibody is in full demand. Something caused a tiny segment of the antibody gene to be showered with a vast number of alterations ??? or mutations. These mutations occurred at levels several million times higher than they do spontaneously throughout the rest of the genome in a cell. This process, known as somatic hypermutation, is crucial because the immune system can then exploit natural selection to enhance the efficacy of an antibody.